In-vitro Evaluation of Pectin as a Compression Coating Material for Colon Targeted Drug Delivery Nitesh Shah*, Tejal Shah and Avani Amin

نویسندگان

  • NITESH SHAH
  • TEJAL SHAH
  • AVANI AMIN
چکیده

Colon targeted delivery of satranidazole (STZ), which immediately releases the drug as soon as the drug delivery system reaches the colon was formulated. Different grades of pectin were used as a compression coat and the effect of degree of esterification (DE) of pectin on swelling and drug release property was evaluated. STZ is a sparingly soluble drug, so to obtain maximum effect of drug at the site of action the solubility enhancement was carried out using Hydroxypropyl-β-cyclodextrin (HP-β-CD). Pectin as a compression coat was unable to direct STZ containing core tablets to the colon, so HPMC was added to increase the tensile strength of the coat. STZ core tablets compression coated with High DE pectin: HPMC in 1:1 ratio imparted the lag time of 5 h and burst release in colon.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/in-vivo Evaluation in Induced Ulcerative Colitis in Rat

Abstract The main objective of this study was to prepare colon-specific pellets of budesonide using pectin as film coating.  Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH o...

متن کامل

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/in-vivo Evaluation in Induced Ulcerative Colitis in Rat

Abstract The main objective of this study was to prepare colon-specific pellets of budesonide using pectin as film coating.  Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH o...

متن کامل

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat

The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...

متن کامل

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat

The main objective of this study was to prepare colon-specific pellets of budesonide, using pectin as film coating. Pellet cores of budesonide were prepared by extrusion / spheronization technique. Pectin, in different ratios was combined with Eudragit RS30D, Eudragit NE30D or Surelease to produce film coating. The dissolution profiles of pectin coated pellets were investigated in pH of 1.2 (2 ...

متن کامل

Formulation and Evaluation of Chondroitin Sulphate Tablets of Aceclofenac for Colon Targeted Drug Delivery

   The aim of the present study was to develop a single unit, site-specific matrix tablets of aceclofenac allowing targeted drug release in the colon with a microbially degradable polymeric carrier, chondroitin suphate (CS) and to coat the optimized batches with a pH dependent polymeric. The tablets were prepared by wet granulation method using starch mucilage as a binding agent and HPMC K-100 ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011